Search results for " abuse"
showing 10 items of 666 documents
Internetbezogene Störungen: Wo kann Prävention ansetzen?
2020
Zusammenfassung Internetbezogene Störungen umfassen unterschiedliche Onlineaktivitäten, die exzessiv entgleiten, das Leben Betroffener dominieren und zu nachhaltigen negativen Folgen führen können. Da internetbezogene Störungen einen chronischen Verlauf nehmen und eine erhöhte psychopathologische Symptombelastung bedingen können, sind wirksame Interventionsprogramme und evaluierte Präventionsangebote dringend notwendig.
¿Por qué (también) es tan difícil legislar sobre juego en España? Un ‘déjà vu’ de lo ocurrido con el alcohol
2016
Regular el juego para prevenir la adicción: hoy más necesario que nunca
2016
En mayo de 2013 aparecio la quinta edicion de la clasificacion de los trastornos mentales (DSM-5) de la American Psychiatric Association (APA, 2013), en la cual se incluye el trastorno de juego dentro de la categoria de trastornos adictivos, que es algo que era demandado desde hace decadas desde los ambitos clinicos, sociales y cientificos. El juego de azar, que segun la propia APA tiene la misma consideracion que las drogas o el alcohol en cuanto a la activacion de los circuitos cerebrales de recompensa y a las consecuencias clinicas del trastorno del juego, no tiene, sin embargo, esa consideracion desde el principal ambito desde donde se debe llevar a cabo la prevencion de la adiccion, qu…
Evaluación de la adaptación de los ítems de consumo del AUDIT para mejor el cribado de Binge Drinking en universitarios
2019
The strong presence of Binge Drinking (BD) amongst university students, as well as the consequences associated with the same and the changes taking place over recent years regarding its conceptualization make it necessary to examine the usefulness of screening instruments used to detect this drinking pattern. This study examines the usefulness of a briefer adaptation of the AUDIT proposed by Cortes, Gimenez, Motos, and Sancerni (2017a). College students self-administered the AUDIT, the revised items 2 and 3 (A2r and A3r), and completed a weekly self-report of their alcohol intake. BD was classified according to the amount consumed and the frequency of that consumption over the past six mont…
Estrés y drogadicción: una perspectiva actualizada para 2020
2020
The role of stress in addiction is complex. In this editorial we highlight the main issues of interest in the ongoing research in relation to drug addiction and stress from an up-to-date perspective. Thus, taking into account that several bibliographic reviews have been published recently on the subject, the aim of this editorial has been to gather updated information in order to point out future directions of research that could make a valuable contribution to the knowledge about addictions and the role that stress plays in them. Finally, we stress the need for interdisciplinary research that addresses stress and addictions by incorporating and integrating physical and psychosocial facto…
Whole-genome sequencing of Neisseria gonorrhoeae in a forensic transmission case.
2019
Abstract Molecular epidemiology and phylogenetic analyses are frequently used in the investigation of viral transmission cases in forensic contexts. Here, we present the methods and results of the analysis of a bacterial transmission episode in an alleged child abuse case using complete genome sequences obtained by high-throughput sequencing (HTS) methods. We obtained genomes of Neisseria gonorrhoeae from the victim, the suspect, and 29 unrelated controls. The analysis of the genomes revealed that the victim and suspect isolates had identical sequences in both the bacterial chromosome and the single plasmid present in them. One of the local controls was very similar (differing in only 2 SNP…
Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament
2015
Traditionally, adversity was defined as the accumulation of environmental events (allostatic load). Recently however, a mismatch between the early and the later (adult) environment (mismatch) has been hypothesized to be critical for disease development, a hypothesis that has not yet been tested explicitly in humans. We explored the impact of timing of life adversity (childhood and past year) on anxiety and depression levels (N = 833) and brain morphology (N = 129). Both remote (childhood) and proximal (recent) adversities were differentially mirrored in morphometric changes in areas critically involved in emotional processing (i.e. amygdala/hippocampus, dorsal anterior cingulate cortex, res…
2018
Haplotypes of the Gabra2 gene encoding the α2-subunit of the GABAA receptor (GABAAR) are associated with drug abuse, suggesting that α2-GABAARs may play an important role in the circuitry underlying drug misuse. The genetic association of Gabra2 haplotypes with cocaine addiction appears to be evident primarily in individuals who had experienced childhood trauma. Given this association of childhood trauma, cocaine abuse and the Gabra2 haplotypes, we have explored in a mouse model of early life adversity (ELA) whether such events influence the behavioral effects of cocaine and if, as suggested by the human studies, α2-GABAARs in the nucleus accumbens (NAc) are involved in these perturbed beha…
Violent offending in borderline personality disorder and attention deficit/hyperactivity disorder.
2018
Abstract The prevalence of borderline personality disorder (BPD) and attention deficit/hyperactivity disorder (ADHD) is significantly higher among offenders compared to the prevalence found in the general population. Both disorders share important diagnostic characteristics and thus it has been suggested that they might follow a common developmental pathway. In this narrative review, we first discuss the potential links of disorder inherent symptoms such as impulsivity and emotion regulation difficulties and how they might elevate the risk of violent delinquency. We continue with highlighting that comorbidities particularly from the antisocial spectrum as well as comorbid substance use diso…
Social defeat stress: mechanisms underlying the increase in rewarding effects of drugs of abuse
2018
Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces longlasting consequence…